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In a healthy volunteer diltiazem drip diltiazem dosage for atrial fibrillation diltiazem 24hr er 180 mg diltiazem other cross-over study (N=10), co-administration of a single 20 mg dose of simvastatin at the end of a 14 day regimen with 120 mg BID diltiazem SR resulted in a 5-fold increase in mean simvastatin AUC versus simvastatin alone .
Subjects with increased average steady-state exposures of diltiazem diltiazem showed a greater fold increase in simvastatin exposure .